Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

Recombinant Human VEGF Protein

别名

重组人VEGF蛋白 | 重组人 VEGF 蛋白

英文别名

货号

rp155965-50μg

包装规格

50μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

纯度

＞95%(SDS-PAGE)

产品介绍

VEGF血管内皮生长因子（Vascular endothelial growth factor），也被称为血管通透因子（Vascular permeability factor，VPF）是一种高度特异性的促血管内皮细胞生长因子，具有促进血管通透性增加、细胞外基质变性、血管内皮细胞迁移、增殖和血管形成等作用。VEGF也被证实对单核细胞和成骨细胞具有趋化作用。 OsrhVEGF是运用基因重组技术，由水稻胚乳细胞表达并通过蛋白提纯工艺而成。 VEGF permeability factor, also known as Vascular permeability factor (VPF), is a highly specific permeability factor for endothelial growth factor. It can promote the increase of vascular permeability, extracellular matrix degeneration, vascular endothelial cell migration, proliferation and angiogenesis. VEGF has also been shown to have chemotaxis on monocytes and osteoblasts.OsrhVEGF is expressed by oryza sativa and purified by protein purification technology.

生化机理

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Post-translational: Produced by use of an alternative upstream CUG codon and post-translationally processed into the N-terminal N-VEGF form and the C-terminal secreted VEGFA form.

生物活性

The ED50 value was lower than 10.0 ng/ml, that is, the corresponding active unit was greater than or equal to 1 x 10^5 units/mg by primary HUVECs cell proliferation method.

来源

重组表达

预测分子量

19.2 kDa

蛋白标签

No tag

SDS-PAGE

19.2 kDa

蛋白长度

Full length protein

表达系统

水稻(Oryza sativa) Accession #: P15692-4 | 水稻(Oryza sativa)

内毒素水平

<0.2 EU/μg

种属

人(Human)

氨基酸

27-191 aa

序列

APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQENPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！