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Product details

名称

Recombinant Human EGF Protein

别名

重组人EGF蛋白

英文别名

货号

rp155969-50μg

包装规格

50μg

级别

无动物源

浓度

≥98%(SDS-PAGE)

纯度

≥95% (SDS-PAGE)

产品介绍

pH值：6.5-7.5 人表皮生长因子（EGF）分子量为6.5kD，含有53个氨基酸，分子内有3个二硫键。EGF与位于细胞表面的特异受体EGFR 结合后，引起细胞内一系列的生化反应：提高细胞内的钙离子浓度水平，促进糖酵解的进行，增加蛋白质的合成，并且可以增强EGFR这一类特定基因的表达来促进DNA 的合成和细胞的增殖。

生化机理

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).

生物活性

Measured in a cell proliferation assay using BALB/3T3 mouse embryo fibroblasts cell line. The ED₅₀ for this effect is typically <1 ng/mL.

来源

重组表达

预测分子量

6.5kD

蛋白标签

No tag

SDS-PAGE

7.1 kDa, under reducing conditions.

蛋白长度

Full length protein

表达系统

毕赤酵母 Accession #: P01133 | 毕赤酵母

内毒素水平

<1.0 EU/mg

种属

人(Human)

氨基酸

971-1023 aa

序列

NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELR

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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