Recombinant Human IL-21 Protein

重组人IL-21蛋白 | 重组人 IL-21 蛋白

CVID11 | IL21 | IL-21 | IL-21Za11interleukin-21 | interleukin 21 | interleukin-21 isoform | Za11

rp156003-50μg

50μg

无载体

≥95%(SDS-PAGE)

Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).

Immobilized Recombinant Human IL-21R Protein (rp147505) at 2.0 μg/mL can bind Recombinant Human IL-21 Protein (rp156003) with the EC50 of 111.90 ng/mL

重组表达

17.8 kDa

N-His

17.3 kDa, under reducing conditions; 16.9 kDa, under non-reducing conditions

E. coli Accession #: Q9HBE4 | E. coli

<1.0 EU/μg

人(Human)

30-162 aa

MGSSHHHHHHSSGLVPRGSHMQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS

No

Yes