Recombinant Human IFN-alpha-2B Protein

重组人 IFN-alpha-2B 蛋白

IFN-alpha-2 | Interferon alpha-A | LeIF A

rp156087-1mg

1mg

无动物源

≥98%(SDS-PAGE&HPLC)

＞98% ( SDS-PAGE and HPLC)

干扰素（IFN）以其在宿主防御机制中的关键作用而闻名。Ⅰ型干扰素包括IFN-alpha 家族，IFN-beta， -omega，-kappa 和 Limitin/IFN-zeta，对调节病毒感染的免疫应答具有重要意义。Ⅱ型干扰素组仅包括干扰素γ。IFN-γ是一种多功能细胞因子，具有抗增殖、免疫调节和促炎症作用，对免疫应答的许多方面都很重要。Ⅲ型干扰素家族包括IL-29/IFN-lambda 1， IL-28A/IFN-lambda 2， IL-28B/IFN-lambda 3， and IFN-lambda 4。与Ⅰ型干扰素类似，Ⅲ型干扰素具有抗病毒、抗增殖和免疫调节作用。 IFN-αs are proteins secreted by leukocyte. They are mainly involved in innate immune response against viral infection. The IFN-α family has 13 subtypes and 23 different variants. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end.

Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 1.6 × 10^8 IU/mg.

重组表达

19.3 kDa

No tag

Full length protein

酵母 Accession #: P01563 | 酵母

<0.1 EU/μg

人(Human)

24-188 aa

CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE

Yes

Yes