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Product details

名称

Recombinant Human GDNF Protein

别名

重组人 GDNF蛋白 | 重组人胶质细胞源性神经营养因子

英文别名

货号

rp156172-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

生化机理

Glial Cell Line-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-beta superfamily. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. NS0 expressed mature human GDNF lacks 31 residues from the amino-terminus of the predicted sequence. This glycosylated recombinant mature human GDNF still contains the seven conserved Cys residues found in all members of the TGF-beta superfamily and is biologically active. The GDNF sequence contains two potential glycosylation sites and insect cell‑expressed recombinant rat GDNF proteins are glycosylated. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.

生物活性

Immobilized Recombinant Human GFR alpha-1/GDNF R alpha-1 Protein (rp146402) at 2.0 μg/mL can bind Recombinant human GDNF protein (rp156172) with the EC50 of 3.4 ng/mL.

来源

重组表达

预测分子量

11.7 kDa

蛋白标签

No tag

SDS-PAGE

16.4 kDa, under reducing conditions; 31.5 kDa, under non-reducing conditions.

表达系统

CHO Accession #: P39905 | CHO

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

109-211 aa

序列

GRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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