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Product details

名称

Recombinant Human NRG1-beta 1 Protein

别名

重组人NRG1-beta 1蛋白 | 重组人类 NRG1-beta 1 蛋白

英文别名

货号

rp156330-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

产品介绍

Protein Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

生物活性

Measured in a cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is typically 0.73 ng/mL.

来源

重组表达

预测分子量

8.2 kDa

蛋白标签

No tag

SDS-PAGE

11.1 kDa, under reducing conditions; 11.2 kDa, under non-reducing conditions

表达系统

E. coli Accession #: Q02297-11 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

121-191 aa

序列

TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQK

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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