Recombinant Human ACTA2 Protein

重组人ACTA2蛋白 | 重组人alpha smooth muscle Actin蛋白 | 重组人 ACTA2 蛋白

Alpha-actin-2 | Cell growth-inhibiting gene 46 protein | a actin | AAT6 | ACTA_HUMAN | ACTA2 | Actin alpha 2 smooth muscle aorta | Actin aortic smooth muscle | Actin | aortic smooth muscle | ACTSA | ACTVS | Alpha 2 actin | Alpha actin 2 | Alpha cardiac ac

rp156637-1mg

1mg

无载体

≥90%(SDS-PAGE)

>90% (SDS-PAGE)

Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： ACTA2 is a member of the actin family of proteins, an extremely conserved family of proteins which takes part in cell motility, structure and integrity. Three types of actin isoforms are known: Alpha, beta and gamma. Alpha actins are a main factor of the contractile mechanism, and beta and gamma take part in the regulation of cell motility. ACTA2 is an alpha actin which is located in skeletal muscle. Mutations in ACTA2 cause aortic aneurysm familial thoracic type 6(AAT6). Various alternatively spliced variants, encoding the same protein were identified. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

重组表达

43.0 kDa

N-His

43.2 kDa, under reducing conditions

E. coli Accession #: P62736 | E. coli

人(Human)

1-377 aa

MGHHHHHHMCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

No

Yes