Recombinant Human SDHB Protein

重组人SDHB蛋白 | 重组人SDHB蛋白

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | Iron-sulfur subunit of complex II (Ip) | EC 1.3.5.1 | Ip | Iron-sulfur subunit of complex II

rp156670-50μg

50μg

无载体

≥90%(SDS-PAGE)

Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency.

重组表达

29.8 kDa

N-His

29.7 kDa, reducing conditions; 29.7 kDa, non-reducing conditions

E. coli Accession #: P21912 | E. coli

<1.0 EU/μg

人(Human)

29-280 aa

MGHHHHHHAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV

No

Yes