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名称

Recombinant Human Histone H2B Protein

别名

重组人Histone H2B蛋白 | 重组人类组蛋白 H2B 蛋白

英文别名

H2B/f | H2B-clustered histone 3 | Histone H2B.1 | Histone H2B.f | GL105 | H2B GL105 | H2B histone family member O | H2B histone family member S | H2B.1 | H2B.1 B | H2B.b | H2B.c | H2B.d | H2B.e | H2B.f | H2B.j | H2B.q | H2B/b | H2B/c | H2B/d | H2B/e | H2B

货号

rp156676-1mg

包装规格

1mg

级别

无载体

浓度

≥95%(SDS-PAGE)

纯度

>95% (SDS-PAGE)

产品介绍

Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and 2. subtype diversity in a class(H1, H2A, H2B, H3 or H4) within a species. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation, plasticity, and malignancy processes. However, extracellular histones are a double-edged sword because they also damage host tissue and may cause death. Histones bound to platelets, induced calcium influx, and recruited plasma adhesion proteins such as fibrinogen to induce platelet aggregation. Histone H2B proteins have been studied in a variety of species and are easily detected in most species. The reversible ubiquitylation of histone H2B has long been implicated in transcriptional activation and gene silencing. Phosphorylation of H2B serine 32 occurs in normal cycling and mitogen-stimulated cells. Notably, this phosphorylation is elevated in skin cancer cell lines and tissues compared with normal counterparts. HIST2H2BE is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

来源

重组表达

预测分子量

15.0 kDa

蛋白标签

N-His

表达系统

E. coli Accession #: P33778 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-126 aa

序列

MGHHHHHHMPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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