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Product details

名称

Recombinant Human IL-6/IL-6R alpha Protein

别名

白介素6受体和白介素6复合物重组蛋白

英文别名

IL-6/IL-6R alpha Complex | IL6 | IL6R | CDF | HGF | HSF | BSF2 | IL-6 | BSF-2 | IFNB2 | IFN-beta-2 | IL6Q | gp80 | CD126 | HIES5 | IL-6R | IL6RA | IL6RQ | IL-1Ra | IL-6RA | IL6QTL | IL-6R-1

货号

rp164646-10μg

包装规格

10μg

级别

无动物源

浓度

≥90%(SDS-PAGE)

产品介绍

Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

生物活性

Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2.5-12.5 ng/mL.

来源

重组表达

预测分子量

59 kDa

蛋白标签

C-His

SDS-PAGE

78-93 kDa, under reducing conditions

表达系统

HEK293 Accession #: P08887,P05231 | HEK293

内毒素水平

<0.1 EU/μg

种属

人(Human)

氨基酸

20-358 aa & 30-212 aa

序列

LAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDGGGSGGGSGGGSVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQMHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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