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Product details

名称

Recombinant Influenza A Virus H3N2 Hemagglutinin Protein

别名

重组甲型流感H3(H3N2)蛋白

英文别名

HA | Hemagglutinin | Influenza A H3 | Influenza A virus

货号

rp165989-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

生化机理

与细胞表面含唾液酸的受体结合，使病毒颗粒附着在细胞上。这种附着会诱导病毒通过凝集素依赖性内吞或通过凝集素和洞穴素依赖性途径内化。在决定宿主范围限制和毒力方面发挥重要作用。I 类病毒融合蛋白。通过介导内吞病毒颗粒的膜与内体膜的融合，负责将病毒渗透到细胞质中。内体中的低 pH 会诱导 HA2 发生不可逆的构象变化，释放出融合疏水肽。需要几个三聚体才能形成合格的融合孔。与细胞表面含唾液酸的受体结合，使病毒颗粒附着在细胞上。这种附着会导致约三分之二的病毒颗粒通过凝集素依赖性内吞途径内化，约三分之一的病毒颗粒通过凝集素和洞穴素依赖性途径内化。在决定宿主范围限制和毒力方面发挥重要作用。I 类病毒融合蛋白。通过介导内吞病毒颗粒的膜与内体膜的融合，负责将病毒渗透到细胞质中。内体中的低 pH 会诱导 HA2 发生不可逆的构象变化，释放出融合疏水肽。形成合格的融合孔需要几个三聚体。翻译后：在自然感染中，非活性 HA 在细胞外被支气管上皮细胞分泌的一种或多种类似胰蛋白酶的精氨酸特异性内切蛋白酶成熟为 HA1 和 HA2。已确定的一种蛋白酶可能参与了这一过程，它由肺部的俱乐部细胞分泌。棕榈酰化。

生物活性

Measured by its binding ability in a functional ELISA. When Recombinant Human Galectin-1 immobilized at 10.00 μg/mL, 100 μL/well, the concentration of Recombinant Influenza A Virus H3N2 Hemagglutinin His-tag that produces 50% of the optimal binding response is 0.35-3.50 μg/mL.

来源

重组表达

预测分子量

58 kDa

蛋白标签

C-His

SDS-PAGE

67 - 85 kDa, under reducing conditions; 63 - 76 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: E2E3B0 | HEK293

内毒素水平

<0.1 EU/μg

种属

甲型流感(Influenza A)

氨基酸

17-530 aa

序列

QNLPGNENNAATLCLGHHAVPNGTIVKTITDDQIEVTNATELVQNSSTGKICNNPHKILDGRDCTLIDALLGDPHCDVFQNETWDLFVERSNAFSNCYPYDVPDYASLRSIVASSGTLEFITEGFTWAGVTQNGGSGACKRGPANGFFSRLNWLTKSGNTYPVLNVTMPNNNNFDKLYIWGVHHPSTNQEQTSLYIQASGRVTVSTRRSQQTIIPNIGSRPLVRGQSGRISVYWTIVKPGDVLVINSNGNLIAPRGYFKMRIGKSSIMRSDAPIDTCISECITPNGSIPNEKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMVDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNKVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKVDLWSYNAELLVALENQNTIDLTDSEMNKLFEKTRKQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHNIYRNEAVNNRFQIKGVELKSGYKDWHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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