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Product details

名称

Recombinant Mouse TNF RII/TNFRSF1B Protein

别名

重组小鼠TNF RII/TNFRSF1B蛋白 | 重组小鼠肿瘤坏死因子受体超家族成员1B蛋白

英文别名

货号

rp166320-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

产品介绍

Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

生物活性

Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D (A113142). The ED50 for this effect is typically 0.95 ng/mL in the presence of 0.5 ng/mL of Recombinant Mouse TNF-alpha Protein (rp154759).

来源

重组表达

预测分子量

52 kDa

蛋白标签

C-hFc & His

SDS-PAGE

60 - 90 kDa, under reducing conditions; 120 - 180 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: P25119 | HEK293

内毒素水平

<0.1 EU/μg

种属

小鼠(Mouse)

氨基酸

23-258 aa

序列

VPAQVVLTPYKPEPGYECQISQEYYDRKAQMCCAKCPPGQYVKHFCNKTSDTVCADCEASMYTQVWNQFRTCLSCSSSCTTDQVEIRACTKQQNRVCACEAGRYCALKTHSGSCRQCMRLSKCGPGFGVASSRAPNGNVLCKACAPGTFSDTTSSTDVCRPHRICSILAIPGNASTDAVCAPESPTLSAIPRTLYVSQPEPTRSQPLDQEPGPSQTPSILTSLGSTPIIEQSTKGGENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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