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Product details

名称

Recombinant Human ZNRF3 Protein

别名

英文别名

货号

rp166398-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

产品介绍

Function E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.

生物活性

Measured by its binding ability in a functional ELISA. When Recombinant Human RSpondin 3 is coated at 0.25 μg/mL, Recombinant Human ZNRF3 binds with an apparent Kd <3 nM.

来源

重组表达

预测分子量

19 kDa

蛋白标签

C-His

SDS-PAGE

18-27 kDa under reducing conditions.

表达系统

HEK293 Accession #: Q9ULT6-1 | HEK293

内毒素水平

<0.1 EU/μg

种属

人(Human)

氨基酸

56-219 aa

序列

KETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

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