Recombinant Human VEGF 165 Protein

重组人VEGF 165蛋白 | 重组人血管内皮生长因子165蛋白

Vascular Endothelial Growth Factor | MVCD1 | VAS | vascular endothelial growth factor A | Vascular permeability factor | Vasculotropin | VEGF | VEGFA | VEGF-A | MGC70609 | VPF | VPFvascular endothelial growth factor | L-VEGF | VEGF165

rp166633-10μg

10μg

无动物源

≥98%(SDS-PAGE)

VEGF 血管内皮生长因子,是一种有效的生长和血管生成细胞因子。 它刺激内皮细胞的增殖和存活，并促进血管生成和血管通透性。 VEGF 在血管化组织中表达，在正常和病理性血管生成中发挥着重要作用。 大量证据表明 VEGF 参与肿瘤转移和眼内新生血管综合征的诱导。 VEGF 通过三种受体发出信号； fms样酪氨酸激酶（flt-1）、KDR基因产物（KDR的鼠同源物是flk-1基因产物）和flt4基因产物。 重组人 VEGF165 是一种 38.2 kDa、二硫键连接的同二聚蛋白，由两条 165 个氨基酸的多肽链组成。 本产品用重组CHO细胞表达生产，高纯度，无动物源性污染。

N-VEGF: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A.Involved in protecting cells from hypoxia-mediated cell death (By similarity). VEGFA: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.Also binds the DEAR/FBXW7-AS1 receptor. Isoform VEGF165B: Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Post-translational: Vascular endothelial growth factor A, long form. Produced by use of an alternative upstream CUG codon and post-translationally processed into the N-terminal N-VEGF form and the C-terminal secreted VEGFA form.

Measured in a cell proliferation assay using Human HUVEC cells. The ED50 for this effect is 1×10^6 IU/mg.

重组表达

20 kDa

C-His

38.2 kDa

CHO Accession #: P15692-4 | CHO

<10 EU/mg

人(Human)

27-191 aa

APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQENPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRRHHHHHH

Yes

Yes