Recombinant Human LILRA2/CD85h/ILT1 Protein

重组人LILRA2/CD85h/ILT1蛋白 | 重组人白细胞免疫球蛋白样受体亚家族A成员2蛋白 | 重组人LILRA2/CD85h/ILT1蛋白 | 重组人白细胞免疫球蛋白样受体亚家族A成员2蛋白

CD85 antigen-like family member H | CD85h antigen | CD85h | ILT1 | ILT-1 | Leukocyte immunoglobulin-like receptor 7 | leukocyte immunoglobulin-like receptor subfamily A member 2 soluble | leukocyte immunoglobulin-like receptor subfamily A member 2 | leuko

rp167152-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens(PubMed:19230061).

Measured by its binding ability in a functional ELISA. When Recombinant Human LILRA2/CD85h/ILT1 is coated at 2 µg/mL, Recombinant Human Angiopoietin-like Protein 7/ANGPTL7 binds with a typical ED50 of 0.2 -1.2 μg/mL.

重组表达

48 kDa

C-His

60 - 90 kDa, under reducing conditions; 60 - 90 kDa, under non-reducing conditions.

HEK293 Accession #: Q8N149-1 | HEK293

<0.1 EU/μg

人(Human)

24-449 aa

GHLPKPTLWAEPGSVIIQGSPVTLRCQGSLQAEEYHLYRENKSASWVRRIQEPGKNGQFPIPSITWEHAGRYHCQYYSHNHSSEYSDPLELVVTGAYSKPTLSALPSPVVTSGGNVTLQCVSQVAFDGFILCKEGEDEHPQRLNSHSHARGWSWAIFSVGPVSPSRRWSYRCYAYDSNSPYVWSLPSDLLELLVPGVSKKPSLSVQPGPMVAPGESLTLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLSQANFTLGPVSPSHGGQYRCYSAHNLSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTVAPGKNVTLLCQSRGQFHTFLLTKEGAGHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGTYRCYSSLSSNPYLLSLPSDPLELVVSEAAETLSPSQNKTDSTTTSLGQHPQDYTVENHHHHHH

Yes

Yes