Recombinant Mouse Chitinase 3-like 1/YKL-40 Protein

软骨糖蛋白39(CHI3L1)重组蛋白

AW208766 | Brp39 | CHI3L1 | Chitinase 3 like 1 | Chitinase 3-like 1 | gp39 | HCgp39 | YKL-40 | Chil1 | chitinase 3 like 1 (cartilage glycoprotein 39) | Chitinase 3 like protein 1 precursor | Chitinase-3-like protein 1 | Chondrocyte protein YKL40

rp167402-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Measured by the ability of the immobilized protein to support the adhesion of FaDu human squamous cell carcinoma cells. When 5 x 10^4 cells per well are added to rmCHI3-L1 coated plate, cell adhesion is enhanced in a dose dependent manner after 30 minutes at 37 °C. The ED50 for this effect is 0.8-3.2 μg/mL. Optimal concentrations should be determined by each laboratory for each application.

重组表达

41.6 kDa

C-His

41 kDa, under reducing conditions

HEK293 Accession #: Q61362-2 | HEK293

<0.1 EU/μg

小鼠(Mouse)

22-381 aa

YKLVCYFTSWSQYREGVGSFLPDAIQPFLCTHIIYSFANISSDNMLSTWEWNDESNYDKLNKLKTRNTNLKTLLSVGGWKFGEKRFSEIASNTERRTAFVRSVAPFLRSYGFDGLDLAWLYPRLRDKQYFSTLIKELNAEFTKEVQPGREKLLLSAALSAGKVAIDTGYDIAQIAQHLDFINLMTYDFHGVWRQITGHHSPLFQGQKDTRFDRYSNVNYAVQYMIRLGAQASKLLMGIPTFGKSFTLASSENQLGAPISGEGLPGRFTKEAGTLAYYEICDFLKGAEVHRLSNEKVPFATKGNQWVGYEDKESVKNKVGFLKEKKLAGAMVWALDLDDFQGTCQPKEFFPLTNAIKDALAHHHHHH

Yes

Yes