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Product details

名称

Recombinant Human Noggin GMP Protein

别名

重组人头蛋白 | 重组人 Noggin GMP 蛋白

英文别名

货号

rp167884-GMP-50μg

包装规格

50μg

级别

无动物源

浓度

≥90%(SDS-PAGE&SEC-HPLC)

生化机理

骨形态发生蛋白（BMP）信号的抑制剂，神经管和体节的生长和模式化需要这种信号。对软骨形态发生和关节形成至关重要。通过与 GDF5 以及 GDF6 的相互作用抑制软骨细胞分化（PubMed:21976273, PubMed:26643732）。

生物活性

Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.1-0.4 μg/mL in the presence of 30 ng/mL of Recombinant Human BMP‑4

来源

重组表达

预测分子量

49.6 kDa (monomer)

蛋白标签

C-hFc

SDS-PAGE

58-62 kDa, under reducing conditions. 110-130 kDa, under non-reducing conditions

表达系统

HEK293 Accession #: Q13253.1 | HEK293

内毒素水平

<0.1 EU/μg

种属

人(Human)

氨基酸

28-232 aa

序列

QHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSCIEGRMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

无动物源

Yes

无载体

Yes

N-末端序列

Amino acid sequencing was blocked, suggesting it is consistent with Gln28 as the first N-terminal amino acid. Predicted N-terminal sequence: Gln28-His-Tyr-Leu-His-Ile-Arg-Pro-Ala-Pro

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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