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Product details

名称

Recombinant Human IL-21 GMP Protein

别名

重组人IL-21蛋白 | 重组人白介素21蛋白 | 重组人 IL-21 GMP 蛋白

英文别名

Interleukin 21 | CVID11 | IL21 | IL-21 | interleukin-21 | interleukin-21 isoform | Za11

货号

rp168289-GMP-25μg

包装规格

25μg

级别

无动物源

浓度

≥95%(SDS-PAGE&SEC-HPLC)

生化机理

具有免疫调节活性的细胞因子。可促进先天性免疫和适应性免疫之间的转换。诱导 B 细胞产生 IgG1 和 IgG3（相似）。参与 T 滤泡辅助细胞（Tfh）的生成和维持以及生殖中心的形成。与 IL6 一起控制 Tfh 细胞的早期生成，是对急性病毒感染做出有效抗体反应的关键（相似）。可能与 IL15 协同作用，在自然杀伤（NK）细胞的增殖和成熟过程中发挥作用。可调节成熟 B 细胞和 T 细胞在活化刺激下的增殖。与 IL15 和 IL18 协同作用，刺激 T 细胞和 NK 细胞产生γ干扰素。在 T 细胞介导的免疫反应中，可能会抑制树突状细胞（DC）的活化和成熟（相似）。

生物活性

Measured in a cell proliferation assay using B9 mouse hybridoma cells. The ED50 for this effect is 5.00-50.0 ng/mL. The specific activity of recombinant human IL-21 is >1.00 x 10^6 units/mg, which is calibrated against an internal reference standard for human IL-21.

来源

重组表达

预测分子量

15 kDa

蛋白标签

No tag

SDS-PAGE

15-17 kDa under reducing conditions.

表达系统

E. coli Accession #: Q9HBE4 | E. coli

内毒素水平

<0.1 EU/μg

种属

人(Human)

氨基酸

32-162 aa

序列

MQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS

无动物源

Yes

无载体

Yes

N-末端序列

Met-Gln32-Asp-Arg-His-Met-Ile-Arg-Met-Arg

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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