Share to
Details
Safety
Related
Technical Documents
Articles
reviews
Consult
returns
Product details
名称
Recombinant Human BMP-2 GMP Protein
别名
重组人BMP-2蛋白 | 重组人骨成型蛋白2蛋白 | 重组人 BMP-2 GMP 蛋白
英文别名
Bone Morphogenetic Protein 2 | BDA2 | BMP2 | BMP-2 | BMP-2A | BMP2A | Bone morphogenetic protein 2A | SSFSC | SSFSC1
货号
rp168355-GMP-10μg
包装规格
10μg
级别
无动物源
浓度
≥95%(SDS-PAGE)
生化机理
属于 TGF-beta 超家族的生长因子,在许多发育过程中发挥着重要作用,包括心脏生成、神经生成和骨生成。诱导软骨和骨形成。通过与 I 型受体 BMPR1A 和 II 型受体 BMPR2 结合,启动典型的 BMP 信号级联。一旦这三种成分在细胞表面结合成复合物,BMPR2 就会磷酸化并激活 BMPR1A。反过来,BMPR1A 通过磷酸化 SMAD1/5/8 传播信号,SMAD1/5/8 进入细胞核,成为靶基因转录的激活剂和抑制剂。通过与其受体 BMPR1A/ALK3 相互作用,还能促进 HAMP 的表达。还可通过非经典途径(如 ERK/MAP 激酶信号级联)发出信号,调节成骨细胞的分化。还可通过 EIF2AK3-EIF2A-ATF4 通路刺激 EIF2A 磷酸化,导致 ATF4 的表达增加,从而刺激成肌细胞向成骨细胞分化,而 ATF4 在成骨细胞分化中发挥着核心作用。在间充质牙胚形成过程中,作为牙胚分化的正向调节因子,其表达在钟形阶段受到 MSX1 介导的 CTNNB1 信号抑制。
生物活性
Measured by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is <0.5 ug/ml.
来源
重组表达
预测分子量
12.9 kDa (monomer)
蛋白标签
No tag
SDS-PAGE
15-16 kDa, reducing conditions
表达系统
E. coli Accession #: P12643 | E. coli
内毒素水平
<0.1 EU/μg
种属
人(Human)
氨基酸
283-396 aa
序列
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
无动物源
Yes
无载体
Yes
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
user reviews
Loading...
Consultation

Warm reminder:

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.!

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ,We will handle it for you as soon as possible, thank you for your support and trust.!

Research chemical ≥95%

Research chemical ≥95%; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%.

item number:rp168355-GMP-10μg
Product model:10μg
level: ≥95%
Lead Time:30days
sold 828 Items
Ask Solution engineer
Specifications:

10μg

Qty

Recommended for you