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Product details

名称

Recombinant Human GDNF GMP Protein

别名

重组人GDNF蛋白 | 重组人胶质细胞系来源神经营养因子蛋白 | 重组人 GDNF GMP 蛋白

英文别名

货号

rp168357-GMP-10μg

包装规格

10μg

级别

无动物源

浓度

≥97%(SDS-PAGE&SEC-HPLC)

生化机理

神经营养因子，可提高多巴胺能神经元的存活率和形态分化，并增加其对多巴胺的高亲和力摄取。它通过与其核心受体 GFRA1 结合，导致 RET 受体的自身磷酸化和激活。参与神经嵴的发育。

生物活性

Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is 2-12 ng/mL in the presence of Recombinant Human GFRα‑1/GDNF Rα‑1 Fc Chimera. The specific activity of recombinant human GDNF is >5.0 x 10^5 units/mg, which is calibrated against the human GDNF Reference Standard (NIBSC code: 09/266). Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GFRα‑1/GDNF Rα‑1 Fc Chimera at 1 µg/mL can bind Recombinant Human GDNF with an apparent Kd <1 nM.

来源

重组表达

预测分子量

11.6 kDa (monomer)

蛋白标签

No tag

SDS-PAGE

17 kDa, reducing conditions. 33 kDa, non-reducing conditions.

表达系统

HEK293 Accession #: P39905-1 | HEK293

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

109-211 aa

序列

RGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI

无动物源

Yes

无载体

Yes

N-末端序列

-Arg109-Gly-Gln-Arg-Gly-Lys-Asn-Arg-Gly-(Cys)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

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