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Product details

名称

Recombinant Human IL-1 beta/IL-1F2 GMP Protein

别名

重组人IL-1 beta/IL-1F2蛋白 | 重组人白介素1β蛋白 | 重组人 IL-1 beta/IL-1F2 GMP 蛋白

英文别名

货号

rp168388-GMP-100μg

包装规格

100μg

级别

无动物源

浓度

≥97%(SDS-PAGE&SEC-HPLC)

生化机理

强效促炎细胞因子。最初是作为主要的内源性热原被发现的，它能诱导前列腺素合成、中性粒细胞流入和活化、T 细胞活化和细胞因子产生、B 细胞活化和抗体产生，以及成纤维细胞增殖和胶原蛋白产生。促进 T 细胞 Th17 分化。与 IL12/白细胞介素-12协同诱导 Thelper 1（Th1）细胞合成 IFNG。与 TNF 和 IL6 协同诱导血管内皮生长因子的产生，从而在血管生成中发挥作用。参与热渗透下游的炎症传导：其成熟形式通过 gasdermin-D (GSDMD) 孔隙特异性地释放到细胞外环境中。作为皮肤化脓性链球菌感染的传感器：被化脓性链球菌 SpeB 蛋白酶裂解并激活，导致炎症反应，从而在皮肤侵入性感染期间阻止细菌生长。翻译后：IL1B 前体的激活涉及 CASP1 催化的蛋白水解。加工和分泌暂时相关。

生物活性

Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 5.0 x 10^7 IU/mg, which is calibrated against the human IL-1 beta WHO International Standard (NIBSC code: 86/680).

来源

重组表达

预测分子量

17 kDa

蛋白标签

No tag

SDS-PAGE

17 kDa under reducing conditions.

表达系统

E. coli Accession #: P01584 | E. coli

内毒素水平

<0.01 EU/μg

种属

人(Human)

氨基酸

117-269 aa

序列

APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

无动物源

Yes

无载体

Yes

N-末端序列

Ala-Pro-Val-Arg-Ser-Leu-Asn-(Cys)-Thr-Leu & Pro-Val-Arg-Ser-Leu-Asn-(Cys)-Thr-Leu-Arg

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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