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Product details

名称

Recombinant Human EGF GMP Protein

别名

重组人EGF蛋白 | 重组人表皮生长因子蛋白 | 重组人EGF GMP蛋白

英文别名

货号

rp168403-GMP-200μg

包装规格

200μg

级别

无动物源

浓度

≥97%(SDS-PAGE&SEC-HPLC)

生化机理

表皮生长因子能刺激体内和体外各种表皮和上皮组织以及细胞培养中某些成纤维细胞的生长。促镁激素，通过表皮生长因子受体的参与和镁通道 TRPM6 的激活，刺激肾远端曲小管对镁的重吸收。可在体外诱导池塘蜗牛（Lymnaea stagnalis）运动神经元的神经元突起。翻译后：O 型糖基化，具有类似核心 1 和核心 2 的糖基。尚不确定是 Ser-954 还是 Thr-955 被 O 型糖基化。这里的修饰显示了糖的异质性：HexHexNAc（主要）和 Hex2HexNAc2（次要）。

生物活性

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 20‑100 pg/mL. The specific activity of Recombinant Human EGF is >8.0 x 10^5 IU/mg, which is calibrated against the human EGF WHO International Standard (NIBSC code: 91/530).

来源

重组表达

预测分子量

6 kDa

蛋白标签

No tag/C-His tag

SDS-PAGE

6 kDa under reducing conditions.

表达系统

E. coli Accession #: P01133-1 | E. coli

内毒素水平

<0.1 EU/μg

种属

人(Human)

氨基酸

971-1023 aa

序列

MNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELR

无动物源

Yes

无载体

Yes

N-末端序列

Met-Asn971-Ser-Asp-Ser-Glu-(Cys)-Pro-Leu-Ser

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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