Recombinant Human ASGR1/ASGPR1 Protein

重组人ASGR1/ASGPR1蛋白 | 重组人 ASGR1/ASGPR1 蛋白

ASGP-R 1 | ASGPR | ASGPR 1 | ASGPR1 | Asgr1 | ASGR1 | ASGR1_HUMAN | Asialoglycoprotein receptor 1 | C type lectin domain family 4 member H1 | C-type lectin domain family 4 member H1 | CLEC4H1 | Hepatic lectin H1 | HL-1 | MHL1 | RHL1

rp169552-50μg

50μg

无动物源

≥95%(SDS-PAGE)

>95% (SDS-PAGE)

Purity: >95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.

Measured by its binding ability in a functional ELISA. SARS-CoV-2 Spike BRD (rp155929) at 0.5 μg/mL can bind Human ASGR1/ASGPR1(biotin) (rp169552) with the EC50 of 491.2 ng/mL.

重组表达

27.2 kDa

N-His

38.0 kDa, under reducing conditions; 35.8 kDa, under non-reducing conditions

HEK293 Accession #: P07306 | HEK293

<1.0 EU/μg

人(Human)

62-291 aa

HHHHHHQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Yes

Yes