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Product details

名称

Recombinant Human CD47 Protein

别名

重组人CD47蛋白

英文别名

货号

rp169585-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

生化机理

CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

生物活性

Immobilized Recombinant Human SIRP alpha/CD172a protein (rp183642) at 2.0 μg/mL can bind Recombinant Human CD47 protein (rp169585) with the EC50 of 308.6 ng/mL. Immobilized Recombinant Human CD47 protein (rp169585) at 1.0 μg/mL can bind Ligufalimab (anti-CD47) (Ab191922) with the EC50 of 62.0 ng/mL.

来源

重组表达

预测分子量

14.5 kDa

蛋白标签

No tag

SDS-PAGE

32.1-40.9 kDa, under reducing conditions; 46.4-63.5 kDa, under non-reducing conditions.

表达系统

CHO Accession #: Q08722 | CHO

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-139 aa

序列

GPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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