Recombinant Human C-Reactive Protein/CRP Protein

重组人C-Reactive Protein/CRP蛋白 | 重组人类 C 反应蛋白/CRP 蛋白

C-Reactive Protein | C-reactive protein, pentraxin-related | pentraxin 1 | PTX1MGC149895 Pentraxin 1, short | C reactive protein | C reactive protein pentraxin related | C-reactive protein(1-205) | CRP | CRP_HUMAN | MGC88244 | Pentraxin 1 | PTX 1 | PTX1

rp169601-50μg

50μg

无动物源

≥95%(SDS-PAGE)

>95% (SDS-PAGE)

Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining Description: CRP is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are non-covalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL-6, IL-1 and glucocorticoids are the major inducer of the CRP gene. In response to infection, inflammation or tissue damage, the level of CRP in human serum can increase 1,000-fold within 24-48 hours. It will come back to base level of less than 1 μg/mL very fast. Human CRP is an acute-phase serum protein that plays a role in the first line in host innate host defense. Like other pentraxins, CRP exhibits Ca++‑dependent binding to ligands. Phosphocholine (PCh), a constituent of many bacterial and fungal walls, is a principal ligand of CRP. CRP also binds to the membrane of injured cells, membrane and nuclear components of necrotic and apoptotic cells. Upon binding with the ligands, CRP is recognized by C1q and initiates the activation of complement cascade. Ligand bound CRP also binds to Fc gamma RI and Fc gamma RIIa on phagocytes and activates phogocytotic responses. In addition to phogocytosis, CRP also can induce production of hydrogen peroxide and inflammatory cytokines, such as IL-1, IL-6 and TNF‑ alpha by monocytes. With these functions, human CRP is an important serum protein for anti-bacterial pathogen and clearance of damaged and apoptotic cells. However, in mouse, CRP is expressed at very low level and is not an acute phase reactant. Serum amyloid P component (SAP), another pentraxin, is the major acute phase serum protein in mice. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human C-Reactive Protein/CRP (rp169601) at 1.0 μg/mL can bind Recombinant CRP Antibody (Ab007977) with the EC50 of 18.28 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human C-Reactive Protein/CRP (rp169601) at 1.0 μg/mL can bind Recombinant CRP Antibody (Ab007978) with the EC50 of 13.86 ng/mL.

重组表达

23.9 kDa

C-His

24.8 kDa, under reducing conditions

HEK293 Accession #: P02741 | HEK293

<1.0 EU/μg

人(Human)

1-224 aa

MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWPHHHHHH

Yes

Yes