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Product details

名称

Recombinant Human CD45 Protein

别名

重组人CD45蛋白 | 重组蛋白酪氨酸磷酸酶受体C

英文别名

B220 | CD 45 | CD45 | CD45 antigen | CD45R | GP180 | L-CA | LCA | Leukocyte common antigen | loc | Ly-5 | LY5 | homolog of | Lyt-4 | OTTHUMP00000033813 | OTTHUMP00000033816 | OTTHUMP00000033817 | OTTHUMP00000038574 | Protein tyrosine phosphatase receptor

货号

rp169658-10μg

包装规格

10μg

级别

无动物源

浓度

≥90%(SDS-PAGE)

生化机理

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. Post-translational: Heavily N- and O-glycosylated.

生物活性

Immobilized Recombinant Human CD45 Protein (rp169658) at 1.0 μg/mL can bind CD45 Mouse mAb (Ab094902) with the EC50 of 65.4 ng/mL.

来源

重组表达

预测分子量

61.6 kDa

蛋白标签

C-His

SDS-PAGE

131.4-171.2 kDa, under reducing conditions; 124.8-163.5 kDa, under non-reducing conditions.

表达系统

CHO Accession #: P08575 | CHO

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-577 aa

序列

MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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