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Product details

名称

Recombinant Human UbcH5a/UBE2D1 Protein

别名

重组人 UbcH5a/UBE2D1蛋白 | 重组人 UbcH5a/UBE2D1 蛋白

英文别名

货号

rp170402-50μg

包装规格

50μg

级别

无载体

浓度

≥90%(SDS-PAGE)

产品介绍

Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Ubiquitin-conjugating Enzyme H5a (UbcH5a), also known as Ubiquitin-conjugating Enzyme E2D 1 (UBE2D1), is a ubiquitously expressed protein that is related to Stimulator of Iron Transport (SFT). Human UbcH5a/UBE2D1 has a predicted molecular weight of 17 kDa and shares 89% and 88% amino acid (aa) sequence identity with the related family members UbcH5b and UbcH5c, respectively. Human UbcH5a/UBE2D1 shares 100% aa sequence identity with the mouse and rat orthologs. UbcH5a/UBE2D1 has a conserved E2 catalytic core domain that contains an active site cysteine residue, and it interacts with a variety of HECT and RING finger Ubiquitin ligases (E3) to mediate the ubiquitination of specific target proteins. UbcH5a/UBE2D1 interacts with the E3, E6-AP, to conjugate Ubiquitin to the tumor suppressor, p53. Additional protein targets of UbcH5a/UBE2D1 include c-Fos, RIP1, and HIF-1. Pathologically, UbcH5a/UBE2D1 is implicated in protein degradation during cancer and immune responses.

生物活性

Testing in progress

来源

重组表达

预测分子量

17.4 kDa

蛋白标签

N-His

SDS-PAGE

15.3 kDa, under reducing conditions; 15.3 kDa, under non-reducing conditions

表达系统

E. coli Accession #: P51668 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-147 aa

序列

MHHHHHHALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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