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Product details

名称

Recombinant Human IL-1ra/IL-1F3 Protein

别名

重组人IL-1ra/IL-1F3蛋白 | 重组人 IL-1ra/IL-1F3 蛋白

英文别名

货号

rp170405-50μg

包装规格

50μg

级别

无载体

浓度

≥95%(SDS-PAGE)

纯度

>95% (SDS-PAGE)

产品介绍

Purity: >95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells, but reportedly will not block binding to the type II receptor on murine pre-B cell lines. The recombinant, non-glycosylated form of IL-1ra blocks binding of IL-1 to its receptor equally as well as the naturally-occurring, glycosylated form. The IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Currently, pre-clinical and clinical studies are underway to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.

生物活性

Testing in progress

来源

重组表达

预测分子量

17.1 kDa

蛋白标签

No tag

SDS-PAGE

15.9 kDa, under reducing conditions; 15.9 kDa, under non-reducing conditions

表达系统

E. coli Accession #: P18510 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

26-177 aa

序列

RPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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