Recombinant Human TL1A/TNFSF15 Protein

重组人TL1A/TNFSF15蛋白 | 重组人TL1A/TNFSF15蛋白 | 重组人 TL1A/TNFSF15 蛋白

MGC129934 | MGC129935 | TL1A | TL1Vascular endothelial cell growth inhibitor | TNF superfamily ligand TL1A | TNFSF15 | tumor necrosis factor (ligand) superfamily, member 15 | tumor necrosis factor ligand superfamily member 15 | vascular endothelial growth

rp170417-10μg

10μg

无载体

≥90%(SDS-PAGE)

Protein Function: TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

Measured by its ability to induce apoptosis of TF1 human erythroleukemic cells.The ED50 for this effect is typically 1.15 ng/mL.

重组表达

20.4 kDa

No tag

20.5 kDa, under reducing conditions

E. coli Accession #: O95150 | E. coli

<1.0 EU/μg

人(Human)

72-251 aa

LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL​

No

Yes