Recombinant Human LH alpha/beta Heterodimer Protein, LH 受体激动剂

重组人LH蛋白 | 重组人黄体激素 | 重组人黄体生成素 | 重组人类 LH alpha/beta 异二聚体蛋白

LH alpha/beta Heterodimer | LH | Luteinizing Hormone alpha/beta Heterodimer | HCG | LHA | FSHA | GPA1 | GPHa | TSHA | GPHA1 | CG-ALPHA & CGB4 | HH23 | LSH-B | LSH-beta | CGA | LHB

rp174456-500μg

500μg

无动物源

≥90%(SDS-PAGE)

>90% (SDS-PAGE)

Purity >90% SDS-PAGE. Background: Luteinizing Hormone (LH) is a 42 kDa heterodimer belonging to the glycoprotein hormone family. It is composed of noncovalently linked glycosylated alpha and beta chains. The alpha subunit (CG alpha ) is also a component of Follicle-Stimulating Hormone (FSH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin. The unique beta subunit confers the protein’s specific biological action and is responsible for the interaction with its receptor. The approximately 20 kDa human CG alpha subunit shares 73% and 72% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively. The approximately 18 kDa human LH beta subunit shares 71% and 72% aa sequence identity with the mouse and rat orthologs, respectively. Multiple isoforms of LH exist due to differences in the post-translational glycosylation, sialylation, and sulphation modifications of its subunits. The composition, longevity, and activity of the different LH isoforms vary throughout a woman’s menstrual cycle and reproductive life cycle. LH is produced and secreted by the anterior pituitary gland. Its secretion is controlled by Gonadotropin-Releasing Hormone from the hypothalamus; however, LH secretion can also be stimulated by estradiol. LH works in concert with FSH to regulate female reproduction; FSH stimulates follicular growth and LH induces ovulation. LH also drives formation of the corpus luteum by promoting progesterone production. Additionally, LH has been suggested to stimulate the adrenal gland in postmenopausal women to induce secretion of sulfated DHEA, a precursor to androgens. In the testis, LH induces Leydig cell production of testosterone. Hypersecretion of LH has been shown to occur in women with polycystic ovary syndrome and is associated with an increased risk of infertility and miscarriage. Additionally, increased serum LH levels are associated with decreased cognition and have been implicated in the development and progression of Alzheimer’s disease. receptor into an A-frame.

重组表达

55.3kDa

N-His & hFc

63.4 kDa, under reducing conditions.

激动剂

LH 受体激动剂

HEK293 Accession #: P01215,P01229 | HEK293

<1.0 EU/μg

人(Human)

25-116 aa & 21-141 aa

APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKSGGGGSGGGGSGGGGSSREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL

Yes

No