Recombinant Human IL15&IL15RA Protein, 白细胞介素-15 受体激动剂

重组人IL15&IL15RA蛋白

ALT-803 | IL-15 N72D:IL-15RαSu/Fc | IL-15SA | N-803 | IL-15 Receptor alpha & IL-15 Fusion Protein | IL15RA&IL15 | IL15RA&IL15 Complex | IL 15 | IL-15 | IL15 | IL15_HUMAN | Interleukin 15 | Interleukin-15 | Interleukin15 | MGC9721 | AA690181 | CD215 | I15R

rp175449-10μg

10μg

无动物源

≥95%(SDS-PAGE)

IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. The enhanced activity of the IL-15N72D:IL-15RαSu/Fc complex is likely the result of the increased binding activity of IL-15N72D to IL-15Rβγ c, optimized cytokine trans-presentation by the IL-15RαSu domain, the dimeric nature of the cytokine domain and its increased in vivo half-life compared to IL-15. These findings indicate that this IL-15 superagonist complex could serve as a superior immunostimulatory therapeutic agent. Post-translational: IL15RA: N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.

Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.

重组表达

47.9 kDa

C-hFc

48 kDa, under reducing conditions.

激动剂

白细胞介素-15 受体激动剂

HEK293 Accession #: P40933,Q13261 | HEK293

<0.1 EU/μg

人(Human)

31-96 aa & 49-162 aa (N120D)

ITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDGGGSGGGSGGGSNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANDSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTSENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

Yes

Yes