Recombinant Human PD-L2/B7-DC Protein

重组人PD-L2/B7-DC蛋白 | 重组人细胞程序性死亡蛋白1配体2

B7-DC | bA574F11.2 | Btdc | Butyrophilin B7-DC | Butyrophilin-like Protein | CD273 antigen | CD273 | CD273PD-1 ligand 2 | MGC142240 | PD-1-ligand 2 | PDCD1L2MGC142238 | PDCD1LG2 | PDL2 | PD-L2 | PDL2B7DC | PD-L2PDCD1 ligand 2 | programmed cell death 1 lig

rp176243-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Programmed Death Ligand 2 (PD-L2), also known as B7-DC and butyrophilin-like protein, is a member of the B7 family of proteins that provide signals for regulating T-cell activation and tolerance. Mature human PD-L2 consists of a 201 amino acid (aa) extracellular domain (ECD) with one V-like and one C-like Ig domain, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain. Within the ECD, mouse and human PD-L2 share 72% aa sequence identity. Alternative splicing generates additional isoforms that lack the second Ig-like domain and may be substituted and truncated following the first Ig-like domain. PD-L2 is expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites such as rheumatoid arthritis, allergen exposure, and virus infection, PD-L2 is up-regulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand up-regulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.

Immobilized Recombinant Human PD-L2/B7-DC Protein (rp176243) at 3.0 μg/mL can bind PD-L2/CD273 Mouse mAb (Ab121048) with the EC50 of 127.6 ng/mL.

重组表达

23.4 kDa

C-His

33.2-44.7 kDa, under reducing conditions; 33.2-44.7 kDa, under non-reducing conditions.

HEK293 Accession #: Q9BQ51 | HEK293

<1.0 EU/μg

人(Human)

1-219 aa

MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPHHHHHH

Yes

Yes