Recombinant Bovine CD16 Protein

重组牛CD16蛋白 | 重组牛 CD16 蛋白

Low affinity immunoglobulin gamma Fc region receptor III-A | IgG Fc receptor III-A | Fc-gamma RIII-alpha FcgammaRIIIA | CD16a | CD16 | FCGR3A | FCGR3 | FCGRIII

rp176262-50μg

50μg

无动物源

≥95%(SDS-PAGE)

>95% (SDS-PAGE)

Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (By similarity).

重组表达

22.4 kDa

C-His

32.5-41.5 kDa, under reducing conditions; 31.3-40.3 kDa, under non-reducing conditions

HEK293 Accession #: P79107 | HEK293

<1.0 EU/μg

牛(Bovine)

17-208 aa

DTQTADPSKAVVLLDPQWNHVLTNDRVTLKCQGDYPVEDNSTKWWHNGTLISSQTPSYFIADVKVQDSGEYKCQTGLSAPSDPVKLEVHVGWLLLQVAQRVVNVGKPIRLKCHSWKKTPVAKVQYFRNGRGKKYSHGNSDFHIPEAKLEHSGSYFCRGIIGSKNESSESVQITVQAPETLQTVSSFFLPWHQHHHHHH

Yes

Yes