Recombinant Human EGFR Protein

重组人EGFR蛋白 | 重组人表皮生长因子受体 | 重组人 EGFR 蛋白

cell growth inhibiting protein 40 | avian erythroblastic leukemia viral (v-erb-b) oncogene homolog | cell proliferation-inducing protein 61 | EC 2.7.10 | EC 2.7.10.1 | EGF R | EGFR | epidermal growth factor receptor (avian erythroblastic leukemia viral (v

rp176273-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Protein Function： As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 25.83 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 28.96 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Nimotuzumab (anti-EGFR) (Ab175612) with the EC50 of 45.18 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Serclutamab (anti-EGFR) (Ab182867) with the EC50 of 35.7 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC50 of 17.44 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Panitumumab (anti-EGFR) (Ab169317) with the EC50 of 23.66 ng/mL.

重组表达

69.4 kDa

C-His

99.6 kDa, under reducing conditions; 99.6 kDa, under non-reducing conditions

HEK293 Accession #: P00533 | HEK293

<1.0 EU/μg

人(Human)

1-645 aa

MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSHHHHHH

Yes

Yes