Recombinant Human EGFR Isoform vIII Protein

重组人EGFR Isoform vIII蛋白 | 重组人类 EGFR 异构体 vIII 蛋白

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog | cell growth inhibiting protein 40 | cell proliferation-inducing protein 61 | EC 2.7.10 | EC 2.7.10.1 | EGF R | EGFR | epidermal growth factor receptor (avian erythroblastic leukemia viral (v

rp176275-50μg

50μg

无动物源

≥95%(SDS-PAGE)

Protein Function: As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Immobilized Recombinant Human EGFR Isoform vIII Protein (rp176275) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 19.11 ng/mL. Immobilized Recombinant Human EGFR Isoform vIII Protein (rp176275) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 22.53 ng/mL.

重组表达

41.7 kDa

C-His

56.2-67.2 kDa, under reducing conditions

HEK293 Accession #: NP_001333870.1 | HEK293

<1.0 EU/μg

人(Human)

1-378 aa

MRPSGTAGAALLALLAALCPASRALEEKKGNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSHHHHHH

Yes

Yes