Recombinant Human CTLA-4 Protein

重组人CTLA-4蛋白 | 重组人 CTLA-4 蛋白

CD | CD152 antigen | CD152 | CD152IDDM12 | CD28 | celiac disease 3 | CELIAC3 | CTLA4 | CTLA-4 | cytotoxic T-lymphocyte antigen 4 | cytotoxic T-lymphocyte protein 4 | Cytotoxic T-lymphocyte-associated antigen 4 | cytotoxic T-lymphocyte-associated protein 4

rp176276-50μg

50μg

无动物源

≥95%(SDS-PAGE)

Purity:≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

Immobilized Recombinant Human CTLA-4 Protein (rp176276) at 1.0 μg/mL can bind Ipilimumab (anti-CTLA-4) (I411993) with the EC50 of 18.49 ng/mL.

重组表达

14.5 kDa

C-His

24.8 kDa, under reducing conditions

HEK293 Accession #: P16410-1 | HEK293

<1.0 EU/μg

人(Human)

1-162 aa

MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFHHHHHH

Yes

Yes