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Product details

名称

Recombinant Human TROP-2 Protein

别名

重组人TROP-2蛋白 | 重组人 TROP-2 蛋白

英文别名

货号

rp176296-50μg

包装规格

50μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

产品介绍

Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

生物活性

Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. The ED50 for this effect is 0.72 μg/mL.

来源

重组表达

预测分子量

28.7 kDa

蛋白标签

C-His

SDS-PAGE

38.5-49.9 kDa, under reducing conditions; 36.5-48.5 kDa, under non-reducing conditions

表达系统

HEK293 Accession #: P09758 | HEK293

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-274 aa

序列

MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTHHHHHH

无动物源

Yes

无载体

Yes

N-末端序列

His27

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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