Recombinant Human TIMP-1 Protein

重组人TIMP-1蛋白 | 重组人基质金属蛋白酶组织抑制因子1蛋白

CLGI | Collagenase inhibitor | collagenase inhibitor) | EPATIMP-1 | EPO | erythroid potentiating activity | Erythroid-potentiating activity | Fibroblast collagenase inhibitor | FLJ90373 | HCI | metalloproteinase inhibitor 1 | TIMP metallopeptidase inhibit

rp176695-10μg

10μg

无动物源

≥95%(SDS-PAGE)

TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP-1/TIMP1 is found in fetal and adult tissues. Highest levels are found in bone, lung, ovary and uterus. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1/TIMP1 mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. In addition to its inhibitory role against most of the known MMPs, the protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this protein encoding gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This encoding gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1/TIMP1 is Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Post-translational: The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated.

Immobilized Recombinant Human TIMP-1 Protein (rp176695) at 1.0 μg/mL can bind TIMP1 Antibody (Ab131327) with the EC50 of 10.0 ng/mL.

重组表达

21.5 kDa

C-His

28.1-34.9 kDa, under reducing conditions; 28.8-35.2 kDa, under non-reducing conditions.

HEK293 Accession #: P01033 | HEK293

<1.0 EU/μg

人(Human)

1-207 aa

MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIAHHHHHH​

Yes

Yes