Recombinant Human TIM-3 Protein

重组人TIM-3蛋白 | 重组人类 TIM-3 蛋白

FLJ14428 | HAVCR2 | HAVcr-2 | hepatitis A virus cellular receptor 2 | kidney injury molecule-3 | KIM-3 | SPTCL | T cell immunoglobulin mucin 3 | CD366 | T cell immunoglobulin mucin-3 | T-cell immunoglobulin and mucin domain-containing protein 3 | TIM 3 |

rp176703-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Protein Function:： Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both the mouse and human. Recently, the identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In the tumor rejection model, the soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in the tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.

Immobilized Recombinant Human Galectin-9 Protein at 1.0 μg/mL can bind Recombinant Human TIM-3 Protein (rp176703) with the EC50 of 1.267 μg/mL. Immobilized Recombinant Human TIM-3 Protein (rp176703) at 1.0 μg/mL can bind Surzebiclimab (anti-TIM-3) (Ab182869) with the EC50 of 15.3 ng/mL.

重组表达

20.7 kDa

C-His

40.0-50.0 kDa, under reducing conditions; 48.0 & 65.0-90.0 kDa, under non-reducing conditions

HEK293 Accession #: Q8TDQ0 | HEK293

<1.0 EU/μg

人(Human)

1-200 aa

MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRHHHHHH

Yes

Yes