Recombinant Human Heme Oxygenase 1 Protein

重组人血红素加氧酶 1 蛋白

bK286B10 | EC 1.14.99.3 | heat shock protein, 32-kD | heme oxygenase (decycling) 1 | HMOX1 | HO | HO1 | HO-1 | HO-1heme oxygenase 1 | HSP32

rp176715-1mg

1mg

无载体

≥98%(SDS-PAGE)

>98% (SDS-PAGE)

Purity:>98%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Heme oxygenase (HMOX) is the rate limiting enzyme in heme catabolism. It cleaves heme to biliverdin, carbon monoxide, and iron. The biliverdin is subsequently converted to bilirubin by biliverdin reductase. The mechanism of HMOX is unique in that heme serves as the substrate of the enzyme and as the prosthetic group for the activation of iron-bound O2. HMOX activity is highest in spleen where senescent erythrocytes are sequestered and destroyed. Two isoforms, HMOX1 and HMOX2, are expressed in most tissues. HMOX1 is an inducible enzyme in response to heme, heavy metals, oxidative stress, cytokines, and many drugs. Whereas HMOX2 displays a constitutive expression. HMOX1 is expressed mainly in spleen, liver, and kidney, and HMOX2 is prominently expressed in the brain and testes. The increased expression of HMOX1 levels is related to a variety of pathological states, where it functions as a cytoprotective molecule through its by products. HMOX1 also plays important roles in the regulation of cell proliferation, differentiation, and apoptosis.

重组表达

30.7 kDa

C-His

28.8 kDa, reducing conditions; 28.8 kDa, non-reducing conditions

E. coli Accession #: P09601 | E. coli

人(Human)

1-261 aa

MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTHHHHHH

No

Yes