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Product details

名称

Recombinant Human SLC39A6/LIV-1 Protein

别名

重组人SLC39A6/LIV-1蛋白 | 重组人锌离子转运蛋白

英文别名

SLC39A6 | LIV-1 | ZIP6 | Zinc transporter ZIP6 | ZIP-6

货号

rp176717-10μg

包装规格

10μg

级别

无动物源

浓度

≥90%(SDS-PAGE)

生化机理

Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). Post-translational: Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation.

生物活性

Immobilized Recombinant Human SLC39A6/LIV-1 Protein (rp176717) at 1.0 μg/mL can bind Ladiratuzumab vedotin (anti-SLC39A6) (Ab183329) with the EC50 of 18.4 ng/mL.

来源

重组表达

预测分子量

61.2 kDa

蛋白标签

C-hFc & His

SDS-PAGE

78.1-99.4 kDa, under reducing conditions; 162.8-239.9 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: Q13433-1 | HEK293

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-325 aa

序列

FPQTTEKISPNWESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIHTSEKKAEIPPKTYSLQIAWENLYFQGPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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