Recombinant Human CD23/Fc epsilon RII Protein

重组人CD23/Fc epsilon RII蛋白 | 重组人Fc epsilon受体II蛋白

BLAST-2 | CD23 | CD23A | CD23CD23 antigen | CLEC4J | CLEC4JC-type lectin domain family 4 member J | C-type lectin domain family 4, member J | Fc epsilon RII | Fc fragment of IgE, low affinity II, receptor for (CD23) | FCE2Fc fragment of IgE, low affinity

rp176722-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor). Post-translational: N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Immobilized Recombinant Human CD23/Fc epsilon RII Protein (rp176722) at 1.0 μg/mL can bind CD23 Antibody (Ab006720) with the EC50 of 106.2 ng/mL.

重组表达

32.2 kDa

N-9His

38.3 kDa, under reducing conditions; 36.3 kDa, under non-reducing conditions.

HEK293 Accession #: P06734 | HEK293

<1.0 EU/μg

人(Human)

48-321 aa

HHHHHHHHHDTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS

Yes

Yes