Recombinant Human UCH-L3 Protein

重组人UCH-L3蛋白 | 重组人 UCH-L3 蛋白

Ubiquitin thioesterase L3 | Ubiquitin thiolesterase | Ubiquitin thiolesterase L3 | UCH L3 | UCH-L3 | UCHL3 | UCHL3_HUMAN | Ubiquitin carboxyl-terminal hydrolase isozyme L3

rp179800-10μg

10μg

无载体

≥95%(SDS-PAGE)

Protein Function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory.

Testing in progress

重组表达

27.0 kDa

N-His

26.9 kDa, under reducing conditions; 26.9 kDa, under non-reducing conditions

E. coli Accession #: P15374 | E. coli

<1.0 EU/μg

人(Human)

2-230 aa

MHHHHHHEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA

No

Yes