Recombinant Human Procalcitonin Protein

重组人Procalcitonin蛋白 | 重组人降钙素原蛋白 | 重组人前降钙素蛋白

CALC1 | CALCA | Calcitonin 1 | calcitonin gene-related peptide 1 | CGRP | Katacalcin | Procalcitonin

rp179804-10μg

10μg

无载体

≥90%(SDS-PAGE)

Procalcitonin (PCT) is encoded by a single CALCA gene, and can result in two alternatively spliced products: calcitonin and calcitonin-gene related peptide (CGRP). Mature PCT is expressed as a 116 amino acid (aa) protein which is subsequently cleaved into three parts: a 57 aa pro-region, a 32 aa Calcitonin peptide, and a 21 aa Katacalcin peptide. PCT is moderately conserved among species, with human sharing 72% and 75% sequence identity with mouse and rat, respectively. In healthy adults, PCT is expressed by thyroid C cells and promptly converted to calcitonin. Calcitonin is directly involved in osteoclast activity and bone resorption. However, in states of inflammatory disease or bacterial infection, PCT is over-expressed from multiple cell types and the levels of unprocessed PCT rise significantly. These increased levels of PCT in circulation have been used as a diagnostic marker of systemic bacterial infection and sepsis and as a guide to antibiotic therapy. More recently, the use of PCT as a disease marker has been expanded to include acute heart failure and vasculitic disorders.

Immobilized Recombinant Human Procalcitonin Protein (rp179804) at 1.0 μg/mL can bind Procalcitonin (PCT) Mouse mAb (Ab008053) with the EC50 of 6.3 ng/mL.

重组表达

27.0 kDa

No tag

12.6 kDa, under reducing conditions; 12.8 & 27.4 kDa, under non-reducing conditions.

E. coli Accession #: P01258 | E. coli

<1.0 EU/μg

人(Human)

27-141 aa

GPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN​

No

Yes