Recombinant Human Galectin-1 Protein

重组人Galectin-1蛋白 | 重组人半乳糖凝集素-1蛋白

14 kDa laminin-binding protein | 14 kDa lectin | Beta-galactoside-binding lectin L-14-I | BHL | DKFZp686E23103 | GAL1 | gal-1 | Galaptin | galectin 1 | Galectin1 | Galectin-1 | GBP | HBL | HLBP14 | HPL | L-14 | Lactose-binding lectin 1 | Lectin galactosid

rp179838-10μg

10μg

无载体

≥95%(SDS-PAGE)

Galectin-1, gene name LGALS1 (lectin, galactoside-binding, soluble 1), is a 135 amino acid (aa), 14 kDa, pleiotropic, non-glycosylated, monomeric or homodimeric carbohydrate-binding protein of the prototype galectin family. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments, or secreted via non-classical pathways. Secreted Galectin-1 has immunosuppressive and anti-inflammatory properties and suppresses acute and chronic inflammation and autoimmunity. It contributes to negative selection of developing T cells, immunosuppression by regulatory T cells, resolution of the inflammatory response, and inhibition of immune cell migration, inflammatory cytokine production, and mast cell degranulation. Galectin-1 preferentially binds laminin, fibronectin, 90K/Mac-2BP, CD45, CD43, CD7, CD2, CD3, integrins alpha 4 beta 1, alpha 5 beta 1 and alpha 4 beta 7, and ganglioside GM1. It is produced in a variety of tissues by cells that include endothelial cells, connective tissue fibroblasts, thymic stromal cells, tumor cells, muscle cells, platelets, regulatory T cells, and activated tissue macrophages, B cells, T cells, and dendritic cells. Most of this expression is cytosolic. Human Galectin-1 shares 88% aa sequence identity with mouse, equine and ovine, 90% with rat, and 87% with bovine and porcine Galectin-1. Endothelial cell surface expression, including tumor endothelial cells, is greatly increased by cell activation. Galectin-1 is highly expressed at the maternal-fetal interface and contributes to fetal immune privilege. Its immunosuppressive properties appear to also allow tumor cells to evade immune detection. It selectively controls T cell survival by inducing apoptosis of activated Th1 and Th17 cells, which express Galectin-1-binding glycans, while promoting Th2 cell survival where glycans are sialylated and less recognized. It also induces apoptosis of immature thymocytes. Galectin-1 secreted from bone marrow stromal cells aids B lymphocyte development by contributing to pre-B cell integrin adhesion and receptor signaling. The dimer form of Galectin-1 also induces neutrophil down‑regulation by inducing cell surface exposure of phosphatidylserine that marks the cell for phagocytosis. Galectin-1 can also modulate cell-cell and cell-matrix interactions, and can promote either cell attachment or detachment depending on the cell type and developmental stage.

Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/mL.

重组表达

14.6 kDa

No tag

12.2 kDa, under reducing conditions

E. coli Accession #: P09382 | E. coli

<1.0 EU/μg

人(Human)

2-135 aa

ACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD

No

Yes