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Product details

名称

Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein

别名

重组人Aldo-keto Reductase 1C3/AKR1C3蛋白 | 重组人醛酮还原酶1C3蛋白

英文别名

货号

rp179839-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

AKR1C3 is a member of the aldo-keto reductase (AKR) superfamily. It catalyzes oxidation/reduction reactions at the 3-alpha, 20-alpha, and 17-beta positions of steroids. It is also known as Prostaglandin F synthase as it reduces prostaglandin D2 to F2, and therefore may play a role in allergic conditions such as asthma. Elevated expression of AKR1C3 in endometrium that results in enhanced estrogen action may lead to endometrial cancer. It is also up‑regulated in squamous cell carcinoma of head and neck. AKR1C3 is found to be a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.

生物活性

Immobilized Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein (rp179839) at 1.0 μg/mL can bind Recombinant AKR1C3 Antibody (Ab087886) with the EC50 of 10.5 ng/mL.

来源

重组表达

预测分子量

37.7 kDa

蛋白标签

N-His

SDS-PAGE

36.4 kDa, under reducing conditions; 36.7 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P42330 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

2-323 aa

序列

MHHHHHHDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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