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Product details

名称

Recombinant Human HTRA1 Protein

别名

重组人HTRA1蛋白 | 重组人 HTRA1 蛋白

英文别名

货号

rp179843-10μg

包装规格

10μg

级别

无载体

浓度

≥90%(SDS-PAGE)

产品介绍

Protein Function:： HTRA1 is a member of the mammalian HTRA (high temperature requirement A) serine protease family. The E. coli HTRA homolog functions as a chaperone-protease and is essential for bacterial survival at temperatures above 42 °C. Among the four mammalian HTRA proteins, HTRA1, -3 and -4 are secreted while HTRA2 is localized in mitochondria. HTRA1 contains an N-terminal insulin-like growth factor binding protein (IGFBP) domain, a Kazal-type trypsin inhibitor motif, and C-terminal trypsin-like protease and PDZ domains. It is involved in several pathologies including Alzheimer’s disease, rheumatoid arthritis, osteoarthritis and age‑related macular degeneration, although the mechanisms by which HTRA1 exerts its effects are not clear. HTRA1 also has properties of a tumor suppressor protein, which makes it a target for cancer therapy. In addition HTRA1 is known to regulate the TGF-beta signaling pathway and bone mineralization. Recombinant human HTRA1 lacks the N-terminal IGFBP and Kazal-like domains, but retains the serine protease and PDZ domains.

生物活性

Casein (0.5 mg/mL) was incubated in 50mM Tris, pH 8.0, or with Recombinant Human HTRA1 Protein (rp179843). After various time intervals aliquots of the reaction mixtures were withdrawn and analyzed by SDS-PAGE.

来源

重组表达

预测分子量

36.3 kDa

蛋白标签

C-His

SDS-PAGE

35.6 kDa, under reducing conditions; 35.6 kDa, under non-reducing conditions

表达系统

E. coli Accession #: Q92743 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

156-480 aa

序列

MGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDPHHHHHH

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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