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Product details

名称

Recombinant Human OX40/TNFRSF4 Protein

别名

重组人OX40/TNFRSF4蛋白 | 重组人TNF受体超家族成员4蛋白

英文别名

货号

rp181285-10μg

包装规格

10μg

级别

无动物源

浓度

≥90%(SDS-PAGE)

生化机理

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.

生物活性

Immobilized Recombinant Human OX40/TNFRSF4 Protein (rp181285) at 1.0 μg/mL can bind BMS-986178 (anti-CD134) (Ab209739) with the EC50 of 38.0 ng/mL. Immobilized Recombinant Human OX40/TNFRSF4 Protein (rp181285) at 1.0 μg/mL can bind Ivuxolimab (anti-CD134) (Ab182815) with the EC50 of 32.7 ng/mL. Immobilized Recombinant Human OX40/TNFRSF4 Protein (rp181285) at 1.0 μg/mL can bind Tavolixizumab (anti-CD134) (Ab182830) with the EC50 of 41.2 ng/mL. Immobilized Recombinant Human OX40/TNFRSF4 Protein (rp181285) at 1.0 μg/mL can bind Cudarolimab (anti-CD134) (Ab182885) with the EC50 of 112.0 ng/mL.

来源

重组表达

预测分子量

23.7 kDa

蛋白标签

C-His

SDS-PAGE

31.6- 49.3 kDa, under reducing conditions; 28.9-49.9 kDa, under non-reducing conditions

表达系统

HEK293 Accession #: P43489 | HEK293

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

1-216 aa

序列

MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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