Recombinant Human Granzyme B Protein

重组人Granzyme B蛋白 | 重组人颗粒酶B蛋白

CCPI | CGL1 | CGL-1 | CSPB | CSP-B | CTLA1 | CTLA-1 | CTSGL1 | Fragmentin-2 | Granzyme B | Granzyme-2 | GranzymeB | GRB | C11 | GrzB | GZMB | HLP | SECT

rp181293-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.

Immobilized Recombinant Human Granzyme B Protein (rp181293) at 1.0 μg/mL can bind Granzyme B Antibody (Ab106347) with the EC50 of 1.923 ng/mL.

重组表达

26.9 kDa

C-His

34.6 kDa, under reducing conditions; 34.6 kDa, under non-reducing conditions

HEK293 Accession #: P10144 | HEK293

<1.0 EU/μg

人(Human)

1-247 aa

MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRYHHHHHHHHHH

Yes

Yes