Recombinant Human HE4/WFDC2 Protein

重组人HE4/WFDC2 蛋白 | 重组人 HE4/WFDC2 蛋白

dJ461P17.6 | EDDM4 | Epididymal secretory protein E4 | epididymis-specific, whey-acidic protein type, four-disulfide core | HE4 | HE4MGC57529 | Major epididymis-specific protein E4 | Putative protease inhibitor WAP5 | WAP domain containing protein HE4-V4

rp181298-50μg

50μg

无动物源

≥95%(SDS-PAGE)

Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： HE4 (also WFDC2; WAP Four-disulfide core domain protein 2) is a secreted, 25 kDa glycoprotein member of the Whey Acidic Protein family of molecules. It is expressed by a wide variety of epithelial cells, including respiratory epithelium, salivary gland mucous cells, breast duct epithelium, distal tubule renal epithelium, and epididymal epithelium. It is believed to play a role in innate defense, and/or function as a protease inhibitor (perhaps for neutrophil elastase). Ovarian epithelial tumors have an increased expression of HE4, leading to the suggestion that HE4 could represent a tumor marker for ovarian cancer. Mature human HE4 is 94 amino acids (aa) in length. It contains two WAP domains that likely mediate antiprotease and/or antimicrobial activity (aa 31‑73 and 74‑123). There are four potential splice variants. One shows a deletion of aa 27‑74, while three others show aa substitutions: 28 aa for aa 75‑124, 23 aa for aa 1‑74, and 10 aa for aa 71‑124. Over aa 31‑124, human HE4 shares 63% aa identity with an extended (144 amino acid) mouse form of mature HE4.

Testing in progress

重组表达

10.8 kDa

C-His

19.3-25.3 kDa, under reducing conditions; 19.3-25.3 kDa, under non-reducing conditions

HEK293 Accession #: Q14508 | HEK293

<1.0 EU/μg

人(Human)

1-124 aa

MPACRLGPLAAALLLSLLLFGFTLVSGTGAEKTGVCPELQADQNCTQECVSDSECADNLKCCSAGCATFCSLPNDKEGSCPQVNINFPQLGLCRDQCQVDSQCPGQMKCCRNGCGKVSCVTPNFHHHHHH

Yes

Yes